Snail1 suppresses TGF-β-induced apoptosis and is sufficient to trigger EMT in hepatocytes
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چکیده
منابع مشابه
Snail: in the cross-roads among EMT and apoptosis
Although Transforming Growth Factor-beta (TGF-β) suppresses early stages of tumour development, it later contributes to tumour progression when cells become resistant to its suppressive effects. Therefore, defining the mechanisms that allow cancer cells to escape from the suppressive effects of TGF-β is fundamental to understand tumour progression and to design specific therapies. TGF-β plays a...
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Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EM...
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ژورنال
عنوان ژورنال: Development
سال: 2010
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.059907